Endocrine Abstracts

Background: Acromegaly is a chronic endocrine disease characterized by excessive secretion of somatotropic hormone (GH), which in turn leads to increased secretion of insulin-like growth factor 1 (IGF-1) in the liver. Many cells in the body are targets for these hormones. Excess of GH, in the vast majority of cases caused by hormone-producing pituitary adenoma, and IGF-1 leads to cellular and tissue growth of practically all organs and systems, including the bone and joint app...